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However, licensing of the medication is restrictive and use varies widely. For example, it is not licensed to treat stroke in people aged 80 years and over, and there is also a question mark about the exact window of time after a stroke where alteplase treatment can be given securely and effectively. The presssing issue of age is important since, in a developed nation like the UK, around one third of strokes each year happen in people aged 80 years and over, ie, about 30 000 people per year. In the to begin the two Articles, Professor Peter Sandercock, University of Edinburgh and Western General Hospital, Edinburgh, UK, and co-workers from the IST-3 collaborative group, report the outcomes of the third International Stroke Trial which sought to determine whether a wider range than hitherto of sufferers treated up to 6 h from stroke onset in scientific trials might advantage .