For instance, the PPAR signaling pathway was upregulated during hibernation and highlights a few of the proteins necessary to maintain center function throughout that process. The group notes these insights could be translated into therapies to avoid and treat coronary disease in humans later on.. Better knowledge of hibernation may help researchers develop remedies for cardiac disease Wintry weather conditions means hats and scarves for a few mammals, and hibernation for others.At these higher doses gentamicin is definitely non-selective and toxic to humans extremely, with irreversible hearing loss being the main negative consequence. In search of a method to bypass these complications, the team led by Professor Timor Baasov of the Technion Faculty of Chemistry modified existing aminoglycoside antibiotic drugs, and monitored biological and toxicity checks of the resulting derivatives carefully. The result is definitely ‘NB54,’ a new chemical substance derivative of gentamicin. ‘We’ve created a new purpose for aminoglycosides by detatching their traditional, natural activities as antibiotics,’ said Baasov. ‘The increased loss of their antibacterial activity makes them highly selective, less toxic, and permits their use in repairing ‘wrong’ genes in human beings.’ So far, the researchers have observed the action of NB54 in ex vivo cell lines.