Dependence on sedation was evaluated by requesting the individual, ”Is sedation necessary for the endoscopic evaluation you merely underwent?” Results Approximately 90 % of individuals surveyed after unsedated colonoscopy or sigmoidoscopy didn’t feel that sedation was essential for the evaluation. No significant variations were observed in pain, acceptance, dependence on sedation, and the rate of complete exam between patients undergoing unsedated colonoscopy and sigmoidoscopy. No complications were noted during or following the process in either combined group. Only 9.4 % of sufferers in the sigmoidoscopy group and 10.8 % of patients in the colonoscopy group considered sedation essential for the procedure.Dr. Nicholls added, The apparent demonstration of benefit at one dose level versus placebo inside our analysis is encouraging. CER-001 warrants further research in medical trials to evaluate its potential benefits for individuals with cardiovascular disease. John F. Paolini, MD, PhD, FACC, Chief Medical Officer of Cerenis, said, While we are disappointed that the principal end point in CHI-SQUARE was not met, the magnitude of the decrease in TAV versus baseline is consistent with what got been seen in the last IVUS trial with the earlier-generation HDL-mimetic ETC-216 reported by Esperion in 2003.