Prize in Chemistry goes to Krishna, Ganesh, IndiaKrishna Ganesh, National Chemical Laboratory, won the TWAS Prize in Chemistry for his outstanding contributions to molecular recognition-based design, synthesis, bioorganic and biophysical studies of novel DNA and PNA with potential applications in therapeutics and diagnostics chemically modified.
Krishna Ganesh is a pioneer in the emerging field of bioorganic chemistry, chemical biology as well as the world, not just in India, but his research into the chemistry of nucleic acids and their interactions with peptides. has resulted in a number of discoveries and applications in a number of different areas.A lot of the research has yet to benefit against this realization man carried out, but to clarify the CLN3 function being just what could help the develop a new treatment. Replace the defective CLN3 in the all that brain neurones is a daunting challenge, however replaces the functionality offered – for example, by activating the corresponding kinase by a drug – should be much more viable.
Vydehi Kanneganti, in collaboration with Prof. All into yeast in yeast: The yeast has been conserved equivalent of mammalian gene CLN3 near remain intact throughout evolution, making them ideal models of to study. In fact, something similar are the yeast and the mammalian genes, when researchers be replaced a lack copy of your yeast gene with in a working copy by the CLN3 mammals, normal functioning of of the yeast cell was restored. The tests showed that equivalent to yeast CLN3 is involved in eventful proteins across the cells – the scientific concept be the gene activates an enzyme the kinase family, which turn launches a series of molecular ‘protein trafficking. ‘events regulating trafficking. Unless the yeast CLN3 a mutation, of these trading is disrupted. As a result specific proteins abnormally enrich themselves in the lysosomes of, the cell of waste recycling machine, instead transported another goal.